Three Week Intensive Neurological Stem Cell Program©

These handouts are designed to help you understand our 3 week program. Since we are not a traditional doctors office you may see equipment or procedures that look unfamiliar to you. While receiving treatment we would like you to be as comfortable and relaxed as possible. Please take the time to read over these handouts to better understand our clinic and the treatment you are about to have.

To paraphrase the second law of thermodynamics, "all organized organisms over time become disorganized and fall apart". To overcome this law the cells of the human body require a constant input of "organizing energy" to develop, maintain and repair themselves. If only we could get this "organizing energy" to work perfectly, the body would be able to repair itself perfectly over and over and old age would become something for the history books!!

My program for Brain Regeneration involves stimulating the person's bone marrow to release as many of these stem cell reserves as possible into the blood stream so they can migrate to the areas that need fixing. No one knows exactly why more stem cells don't normally circulate but the level of circulating stem cells does vary from one person to another. The person who is older and has more medical problems and is out of shape usually has low to non-existent circulating stem cells while the young, healthy person has higher levels. All of this translates into the fact that the more stem cells you have circulating, the more healthy you become since the body then has plenty of that "organizing energy" to organize and repair damaged tissues. This program involves flooding the circulation with the most stem cells and growth factors that can be given safely over a three week + period of time. Stem cells provide the most perfect set of genetic blueprints and repair building blocks that injured tissues and cells need to repair and regenerate themselves. There are many types of stem cells but only one type that is currently legal in the USA . These stem cells are of the type found in a person's bone marrow (the spongy inner part of long bones and pelvis). Bone marrow stem cells are multipotent stem cells which means that they can become a variety of different tissue types (blood cells, nerve tissue, muscle tissue, skin, bones, etc.).

There are two major types of stem cells living quietly and peacefully in the bone marrow. The most well known and studied type is the hematopoietic stem cell (blood cell forming cells). These are actively dividing and releasing their daughter offspring into the blood where they repair the inner lining of your blood vessels. These circulating stem cells help prevent the athero and arteriosclerosis (hardening of the arteries) that occurs if the inner linings do not properly repair their daily wear and tear. Besides helping to repair blood vessel walls, the hematopoietic stem cells also migrate to any area of the body that has been injured or is suffering from a lack of oxygen and help that area to repair itself.

The other type of bone marrow stem cell is called a MESENCHYMAL or stromal cell. The mesenchymal stem cells provide growth factors that help the hematopoietic stem cells to divide and grow so that they can keep up their daily production of new blood cells. The mesenchymal cells generally are released into the blood stream less and less as you age resulting in degenerative joint disease (osteoarthritis), osteoporosis, and collapse and herniation of the vertebral discs. If you flood the body with these types of cells, osteroarthritis is often helped almost immediately. Research studies point to the real possibility of healing all of the joint and disc problems with the appropriate and repetitive use of mesenchymal stem cells. The normal person has about 10 to 15 million hematopoietic stem cells in their blood stream but billions of hematopoietic and mesenchymal stem cells are tucked away in their bone marrow.

A bone marrow transplantation provides hundreds of millions of stem cells in the right proportion of both types to help the body heal itself in the most natural way possible.

Over the past 10 years I have either treated or observed over 1000 patients given stem cell transplants without the use of chemotherapy or radiation. With this experience Dr Anthony Payne and I wrote a book describing some of the results – "Umbical Cord Stem Cell Therapy" which is recommended reading. With these experiences I have learned some general facts regarding this type of therapy.

During this time it has become quite apparent that the more primitive the cells are, the more aggressive the stem cells are in regard to engraftment i.e. success in establishing new tissue growth or repair. Thus embryonic are slightly more aggressive than umbilical which are more aggressive than your own bone marrow stem cells. These differences can be reduced to a large degree by changing the number of cells and the various agents used before, during and after the transplantations. At times a single injection of any of these types of stem cells will be sufficient to create meaningful and beneficial results. However, if you have been reading about stem cell therapy on the internet you probably already know that stem cells act often very much like hyperbaric oxygen does in that both produce "Uncertain Miracles". In other words, often but not always do you get the results you are looking for. I believe that stem cells work and grow in much the same manner as a newly conceived baby does. Just like a newly conceived baby, your newly acquired "little babies" require the optimum of growth factors and fertile tissue to grow in the most perfect way possible. Poisons and toxins of any type and lack of proper growth factors are going to interfere with this perfect growth and may result in the failure of the stem cell transplantation. Mercury and lead are extremely toxic to newly growing tissues and are often part of different neurological degenerative diseases. These and other poisons should be removed from your body to allow the stem cells to grow effectively. Another commonly overlooked source of poisons is the intestinal bacteria, parasites and fungi. Once they or their waste products are absorbed into the blood stream they migrate to the blood-brain-barrier where they activate the neuron supportive "glial"cells. Activation of these supporting glial cells irritates them and this causes these cells to release free radicals that damage the neuron they are supposed to be helping. This "glial activation" can also occur from viruses, lack of oxygen etc. in addition to the debris entering the blood from the intestine. Any one or combination of these (if not corrected) promotes further neurological deterioration in spite of the application of stem cells. Thus proper evaluation and treatment of the patient is usually called for before receiving stem cells especially in any adult patient. The bottom line is that stem cells need fertile, nonpoisoned soil in which to grow successfully.

The bone marrow that is infused into you has hundreds of millions (billions with the procedures mentioned in this article) of the different types of stem cells (mesenchymal and hematopoietic). These stem cells will circulate in your blood until they are attracted to tissues that express certain adhesion molecules on their surface due to either previous injury or poor blood supply. They will become attached fairly quickly within the first 24 hours. From there, they dig their way inside of the damaged tissues and begin to make new blood vessels and secrete growth and repair factors that help the damaged tissues repair themselves. Newly growing blood vessels are extremely fragile and can be disrupted by vibration of the type that occurs with driving. Due to this I don't recommend driving long distances beginning within four days of the transplant. Flying is recommended if at all possible rather than driving home long distances. More rest will be needed for the next three weeks while your babies grow. During this time you should avoid people with colds or other infections. I would wear a surgical mask while flying if possible to prevent catching some germ that will disrupt your new baby's health.

The next most important factor is the amount and degree of tissue damage and when it happened. The most effective time for stem cell transplantation is within the first ten days after a major injury. During this first ten days, days three to seven are the optimum days to give them. Because of the emergency there is no time for evaluating and treating the patient in regard to all of the toxic and growth factors mentioned above since the best results in emergencies are obtained if you give the stem cells within the first 10 days. This ten day rule is not absolute however and in many cases I still will recommend the person receive stem cells immediately and disregard the ten day rule. The reason for that is that everyone and every situation is different and also one never knows when the blood brain barrier has repaired itself fully after an injury. This caveat also pertains to the patient with active neurological disease. In general if you are going downhill and getting worse daily then time is of the essence and I often recommend immediate treatment. After treating, I then begin the process of evaluating and treating the factors that may be contributing to the person's deterioration. The downside of using them is just that you don't see improvement (loss of money) while the positive results you can obtain if the brain barrier is still open are often remarkable.

Stem cells are able to "home in" to sites of the body that need to be repaired because in the areas of injury the damaged tissues send signals to their blood vessel inner lining cells. These blood vessel wall cells generate and express adhesion molecules on their surfaces which attract the stem cells to them. Once the stem cells attach to the blood vessel inner linings they migrate into the damaged tissues where they start to repair and replace the damaged or diseased tissues.

When dealing with an old injury or chronic stable disease the adhesion molecules that attract stem cells have been lost since the blood vessel cells are not being given signals from inside the adjacent tissue that tissue repair is needed.

To achieve significant results in old injuries or stable diseases we must stimulate the blood vessel walls to secrete adhesion molecules once again. To achieve this we need to put temporary stress on the injured tissues which we do with therapies such as ultrasound, electricity, electromagnetic, pressure, heat, cold, hypoxia, etc. With these stimulative treatments you can achieve good results with the right type, amount and placement of the right types of stem cells. Combinations of stem cells work better than a single type. The best combination is when you give 4 to 8 mesenchymal stem cells for every hematopoietic stem cell-- with the optimum quantity of the proper growth factors that are needed to grow the type of tissue you are attempting to grow or repair. The bone marrow procedure provides the optimum ratio of stem cells that has been shown to be needed for optimum growth of the stem cells.

An outline of this approach is:

Day 1 to 5:
Neupogen daily for 5 days
HGH 1 unit daily
Embryonic brain growth factors 5+ ml per day
Forteo 20 mcg subcutaneously daily for one month
External Counter Pulsation daily weekdays for three weeks (15 treatments)- the best results will occur if you stay and do a total of 35 treatments in Toto.

Day 5:
Bone marrow transplant. Approximately 3/4 of your bone marrow aspirate will be given to you intravenously on this day. The other ¼ will be sent to the lab for testing and culturing. [If you want we can grow your cells and test them to see what supplements will help your stem cells the most. This should help your stem cells regain a more youthful and vigorous functionality. There is a significant charge for this procedure. which takes at least three weeks of laboratory work to do.]

Day 6 to 19:
Daily ECP, intermittent hypoxia, pulsed electromagnetic therapy, computerized electrical stimulation, etc as needed

Day 19:
Second bone marrow
Continue ECP if possible, intermittent hypoxia, HGH, forteo (until gone) and embryonic growth factors. Most people will go home that weekend but should carry on with at least the embryonic brain growth factors for two more months.

On day 1 of your therapy you will be receiving an injection called Neupogen® (Filgrastim). This injection is given for 5 days to increase your Hematopoietic stem cells throughout your body. Neupogen® works as a mobilizer and releaser of HSC cells from the bone marrow into the blood stream. The HSCs then migrate to areas of tissue injury (an area of low oxygen) where they assist in repairing and regenerating the damaged tissue.

Also on day 1 you will be given an injection of embryonic growth factors , which is a peptide solution produced form purified brain proteins. These growth factors supports the survival, stability, and function of your stem cells. You will be taking these peptides 5 days a week for at least two months. You may also be given a prescription for HgH Saizen® injection which is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles. And last you will be given a prescription for Forteo® which is an injection that is used to treat osteoporosis by forming new bone. Our lab and others have shown that Forteo® and HgH Saizen® increases the number of bone marrow stem cells 5 to 10x if taken for 2 weeks prior to your bone marrow stem cell procedure.

Five days after beginning the program, you will have the first bone marrow transplant. An IV (intravenous) will be started and then you will receive an IV anesthetic which will make you relaxed and comfortable (you will not be put to sleep under general anesthesia). Please let both your doctor and nurse know if you have any allergies to medications before your procedure begins! A local anesthetic (lidocaine) will be injected into one side of your pelvic bone (iliac crest) prior to the bone marrow procedure. A needle is then inserted through the skin into the iliac crest (pelvic bone). The doctor then removes the bone marrow through the needle into several large syringes. The marrow is stored in a bag with a special no-clot solution. After the needle is removed a suture glue is applied to the needle incision site. The area is then cleaned and covered with a bandage. After the procedure is over your bag of bone marrow is hung and returned back into your blood stream through the IV.

On day 1 you will start treatment on a machine called External Counter Pulsation (ECP). ECP is a medical device pioneered by Harvard and MIT that improves circulation to the heart, brain, kidneys, eyes and other internal organs. Large blood pressure cuffs will be placed on your thighs and calves. Thsese cuffs will inflate and deflate in-sync with your heart rate. The increaced pressure creates an "augmented", or larger pulse volume which delivers more blood to your internal organs during diastole (when the heart is at rest between beats). It also stimulates the formation of a stem cell and new blood vessel growth hormone called VEGF (vascular endothelial growth factor). During day 1-2 you will also receive treatment by Pulsed Electro-Magnetic Frequencies (PEMF). PEMF deeply penetrates muscle, organ tissue, connective tissue, and even bone and induces healing electrical currents in your tissues.

Magnatherm, is a high energy pulsed electromagnetic device which can reduce inflammation, improve circulation, and energize cells that need a continued healing effect. It will be used to attract stem cells to a particular area in the body. During these electromagnetic therapies you also receive a treatment called Intermittent Hypoxia Therapy (IHT). This is a breathing treatment done for one hour a day and can be done together with your PEMF therapy. IHT reduces the oxygen content in the air that you breathe, simulating the effects of breathing high mountain air. IHT stresses your cell's mitochondria (the "power house" of the cell) to become more efficient and effective at increasing cellular metabolism. Damaged tissues have damaged blood vessels which prevents proper levels of oxygen from being delivered to these tissues normally. This lack of oxygen is one of the major reasons why tissues do not heal. Intermittant hypoxia causes a temporary worsening of this poor oxygen supply and this stresses the damaged tissues and coaxes them into secreting stem cell adhesion molecules in these damaged blood vessels. These newly produced adhesion molecules then attract the stem cells to the inner linings of the stable, previously damaged tissues so they can enter these tissues and initiate the healing.

Congratulations you have made it to day 19 of your treatment! This day is dedicated to your second bone marrow stem cell procedure. Remember to wear light comfortable clothing on the day of your procedure. Shoes that can slip on and off are best. Do not eat for at least 6 hours prior to the procedure. You may drink water and take your regularly scheduled medications in the morning. It is important that when you go home you continue to eat well and take care of your body. Stem cells are damaged by high stress and poor diet, alcohol, drugs and smoking. Give your body a few days of rest if possible.

As you head home be sure to have your needles and syringes and your brain growth factors with you. It is important to stay on these. In general your results will be twice as good if you follow these instructions and do what I tell you to do. NO ALCOHOL!!!

I hope this has helped you to understand the treatment you are going to receive. If you have any further questions please contact our office at 1 (800) 300-1063 and our nurse will be happy to speak with you.

Thank you!!

Physicians Addendum:
Better results can be obtained for our mutual patient who suffered some injury in the past by doing these tests: DMPS challenge test or if an iv is not possible then a DMSA challenge test with the results being sent to Doctor's Data for toxic element testing.
CDSA plus O&P
Urine organic acids (Doctor's Data).
Blood tests to test for autoimmune problems, iron deficiency, electrolyte imbalances, infections and hormones (thyroid, HGH, IGF-I, testosterone, pregnenolone, estriol, etc. Each case has its own requirements for blood tests so if you have a question, please email me at drsteenblock@yahoo.com and tell me what diagnoses the patient has and I will give you my recommendations as to what blood tests should be done.

After these tests are done, then please treat the heavy metals, yeast, etc as you best see fit. Hormones should be given to bring the body back to more youthful levels. Once these infections, heavy metals and imbalances are cleared and or corrected the patient is ready to move forward.

Next beginning nineteen days from the start of the above program start the patient on five days of neupogen and continuous HGH (one unit per day). This will jump start the patient's bone marrow stem cells so that with our first bone marrow transplant they will have about 5X more stem cells available for transplantation.